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Dose to Volume

5 mg in 5 mL

At most 1.000 mg/mL, which puts 100.0 mcg in each tenth of a millilitre. A 500 mcg amount is at least 0.500 mL, which is at least 50.00 units on a U-100 barrel.

Educational arithmetic only. Not medical advice and not a dosing protocol.

The strength this pair reaches, three ways. Every figure is an upper bound: the solid takes up room once it dissolves, so the finished solution is larger than 5 mL and the real strength is this or lower.
Expressed asAt most
Milligrams per millilitre1.000 mg/mL
Micrograms per millilitre1000.0 mcg/mL
Micrograms in a tenth of a millilitre100.0 mcg

Before you act on that number

This is educational arithmetic on figures entered by the reader. It is not medical advice, not a dosing protocol, and not a recommendation that anything be prepared, obtained or administered.

Nothing here states what quantity is appropriate for anyone, and there is no function in it that produces an amount to administer. A question about anyone’s health belongs with a licensed clinician who can examine the person asking.

Compounds of the kind this arithmetic is used on are largely research chemicals that are not approved by the FDA for human use. An exact calculation is not an accurate measurement: what is actually in a syringe depends on the preparation and the device, neither of which this page can see.

Seven amounts out of this vial. Each volume is at least the figure shown, because it was derived from a strength that is at most the figure above. Reading across gives the volume, then the same volume in microlitres, then the mark on three barrels.
AmountAt least, mLAt least, µLU-100U-50U-40
100 mcg0.10010010.005.004.00
250 mcg0.25025025.0012.5010.00
500 mcg0.50050050.0025.0020.00
750 mcg0.75075075.00past the barrel30.00
1 mg1.0001000100.00past the barrel40.00
1.5 mg1.5001500past the barrelpast the barrelpast the barrel
2.5 mg2.5002500past the barrelpast the barrelpast the barrel

What is particular to this pair

The most dilute pair in the family at exactly 1 mg/mL. Small amounts become long, readable draws: 100 mcg is a tenth of a millilitre, ten clear units on a U-100. The ceiling is the problem instead - anything above 1 mg needs more than a millilitre and will not fit a U-100 barrel in one go.

Five millilitres of solution out of a vial designed to hold a lyophilised cake is also a question about the vial rather than about the arithmetic. Not every container has the headroom, and a calculation that assumes it does is the kind of thing worth checking against the object before trusting the table below.

Why the figures above say "at most" and "at least"

The finished solution is 5 mL of diluent plus the room the dissolved solid takes up, and nobody measured the second part. So the finished volume is at least 5 mL, the strength is at most 1.000 mg/mL, and every volume derived from it is at least the figure shown - which is the useful direction, because it means a reader drawing one has not drawn more than intended.

Why a derived strength is a ceiling covers the size of the gap, and vial into a strength has a field for the measured finished volume that removes the question.

The same vial, other ways in